Cell atlas - MAP3K11 - The Human Protein Atlas

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MAP3K11

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule organizing center

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	MAP3K11
Gene description	Mitogen-activated protein kinase kinase kinase 11
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & microtubule organizing center.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB010165
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & microtubule organizing center.

Main location

Microtubule organizing center (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010165	U-2 OS	Microtubule organizing center
	CAB010165	U-2 OS	Cytosol

GENE INFORMATION
Gene name	MAP3K11 (HGNC Symbol)
Synonyms	MEKK11, MLK3, PTK1, SPRK
Description	Mitogen-activated protein kinase kinase kinase 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65597755 - 65615382
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173327 (version 83.38)
Entrez gene	4296
UniProt	Q16584 (UniProt - Evidence at protein level)
neXtProt	NX_Q16584
Antibodypedia	MAP3K11 antibodies

PROTEIN BROWSER

MAP3K11-001	MAP3K11-004	MAP3K11-006	MAP3K11-012	MAP3K11-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K11-001 ENSP00000309597 ENST00000309100	Q16584 [Direct mapping] Mitogen-activated protein kinase kinase kinase 11 A0A024R5E6 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase 11, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004706 [JUN kinase kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0007254 [JNK cascade] GO:0007256 [activation of JNKK activity] GO:0007257 [activation of JUN kinase activity] GO:0008219 [cell death] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043507 [positive regulation of JUN kinase activity] GO:0043525 [positive regulation of neuron apoptotic process] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048365 [Rac GTPase binding] Show all	847 aa 92.7 kDa	No	0
MAP3K11-004 ENSP00000433886 ENST00000530153	Q16584 [Direct mapping] Mitogen-activated protein kinase kinase kinase 11 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004706 [JUN kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] Show all	590 aa 65.3 kDa	No	0
MAP3K11-006 ENSP00000432068 ENST00000532507	E9PID4 [Direct mapping] Mitogen-activated protein kinase kinase kinase 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		263 aa 27.6 kDa	No	0
MAP3K11-012 ENSP00000435970 ENST00000526293	E9PRQ2 [Direct mapping] Mitogen-activated protein kinase kinase kinase 11 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	111 aa 12.3 kDa	No	0
MAP3K11-013 ENSP00000435237 ENST00000529839	E9PLB1 [Direct mapping] Mitogen-activated protein kinase kinase kinase 11 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	97 aa 10.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.