Cell atlas - KCNK7 - The Human Protein Atlas

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KCNK7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KCNK7
Gene description	Potassium channel, two pore domain subfamily K, member 7
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA077577
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077577	HaCaT	Plasma membrane
	HPA077577	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	KCNK7 (HGNC Symbol)
Synonyms	K2p7.1
Description	Potassium channel, two pore domain subfamily K, member 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65592855 - 65595996
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173338 (version 83.38)
Entrez gene	10089
UniProt	Q9Y2U2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y2U2
Antibodypedia	KCNK7 antibodies

PROTEIN BROWSER

KCNK7-001	KCNK7-002	KCNK7-003	KCNK7-004	KCNK7-005	KCNK7-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK7-001 ENSP00000377764 ENST00000394216	Q9Y2U2 [Direct mapping] Potassium channel subfamily K member 7 A0A024R5F5 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 7, isoform CRA_b Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	257 aa 26.8 kDa	Yes	4
KCNK7-002 ENSP00000377765 ENST00000394217	Q9Y2U2 [Direct mapping] Potassium channel subfamily K member 7 A0A024R5B0 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 7, isoform CRA_c Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	252 aa 26.2 kDa	Yes	4
KCNK7-003 ENSP00000344820 ENST00000340313	Q9Y2U2 [Direct mapping] Potassium channel subfamily K member 7 Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	307 aa 31.9 kDa	No	5
KCNK7-004 ENSP00000343923 ENST00000342202	Q9Y2U2 [Direct mapping] Potassium channel subfamily K member 7 A0A024R5B0 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 7, isoform CRA_c Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	252 aa 26.2 kDa	Yes	4
KCNK7-005 ENSP00000435449 ENST00000525254	H0YEB9 [Direct mapping] Potassium channel subfamily K member 7 Show all	Predicted intracellular proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	28 aa 2.8 kDa	No	0
KCNK7-006 ENSP00000431950 ENST00000530380	H0YCM4 [Direct mapping] Potassium channel subfamily K member 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	72 aa 7.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.