Expression of C1QB in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	C1QB
Gene description	Complement component 1, q subcomponent, B chain
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Not detected
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Low cytoplasmic expression in selected tissues with plasma positivity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA052116
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA052116

GENE INFORMATION
Gene name	C1QB
Synonyms
Description	Complement component 1, q subcomponent, B chain (HGNC Symbol)
Entrez gene summary	This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	22652762 - 22661538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173369 (version 83.38)
Entrez gene	713
UniProt	P02746 (UniProt - Evidence at protein level)
neXtProt	NX_P02746
Antibodypedia	C1QB antibodies

PROTEIN BROWSER

C1QB-001	C1QB-002	C1QB-003	C1QB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1QB-001 ENSP00000423689 ENST00000509305	D6R934 [Direct mapping] Complement C1q subcomponent subunit B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	251 aa 26.5 kDa	Yes	0
C1QB-002 ENSP00000404606 ENST00000432749	A0A0A0MSV6 [Direct mapping] Complement C1q subcomponent subunit B Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	229 aa 24.1 kDa	Yes	0
C1QB-003 ENSP00000426317 ENST00000510260	D6RGJ1 [Direct mapping] Complement C1q subcomponent subunit B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] Show all	153 aa 15.5 kDa	Yes	0
C1QB-201 ENSP00000313967 ENST00000314933	P02746 [Direct mapping] Complement C1q subcomponent subunit B A0A024RAB9 [Target identity:100%; Query identity:100%] Complement component 1, q subcomponent, B chain, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005602 [complement component C1 complex] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0048839 [inner ear development] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	253 aa 26.7 kDa	Yes	0