Tissue expression of OLR1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	OLR1
Gene description	Oxidized low density lipoprotein (lectin-like) receptor 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (appendix, cerebral cortex, lung, placenta)
GTEx:	Tissue enriched (lung)
FANTOM5:	Tissue enhanced (lung, placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, cerebral cortex, lung, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, placenta)

GENE INFORMATION
Gene name	OLR1 (HGNC Symbol)
Synonyms	CLEC8A, LOX-1, SCARE1
Description	Oxidized low density lipoprotein (lectin-like) receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10158301 - 10172138
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173391 (version 83.38)
Entrez gene	4973
UniProt	P78380 (UniProt - Evidence at protein level)
neXtProt	NX_P78380
Antibodypedia	OLR1 antibodies

PROTEIN BROWSER

OLR1-001	OLR1-002	OLR1-003	OLR1-005	OLR1-006	OLR1-007	OLR1-008	OLR1-009	OLR1-010	OLR1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OLR1-001 ENSP00000309124 ENST00000309539	P78380 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form A0A024RAU0 [Target identity:100%; Query identity:100%] Oxidised low density lipoprotein (Lectin-like) receptor 1, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007159 [leukocyte cell-cell adhesion] GO:0007596 [blood coagulation] GO:0008015 [blood circulation] GO:0008219 [cell death] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0042157 [lipoprotein metabolic process] GO:0042542 [response to hydrogen peroxide] GO:0043231 [intracellular membrane-bounded organelle] GO:0043235 [receptor complex] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	273 aa 31 kDa	No	1
OLR1-002 ENSP00000405116 ENST00000432556	P78380 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0008015 [blood circulation] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043235 [receptor complex] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	181 aa 20.2 kDa	No	1
OLR1-003 ENSP00000444457 ENST00000544577	F5GZH1 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	165 aa 18.6 kDa	No	1
OLR1-005 ENSP00000445085 ENST00000543993	B7ZAN8 [Direct mapping] Oxidized low-density lipoprotein receptor 1; cDNA, FLJ79252, weakly similar to Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.7 kDa	No	0
OLR1-006 ENSP00000444068 ENST00000543414	F5H001 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	104 aa 12 kDa	No	0
OLR1-007 ENSP00000442389 ENST00000539518	F5H7N8 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	214 aa 24.5 kDa	No	0
OLR1-008 ENSP00000439251 ENST00000545927	P78380 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006954 [inflammatory response] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0008015 [blood circulation] GO:0016020 [membrane] GO:0030246 [carbohydrate binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043235 [receptor complex] GO:0045121 [membrane raft] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] Show all	189 aa 21.4 kDa	No	1
OLR1-009 ENSP00000438925 ENST00000538745	F5H3G7 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 14.3 kDa	No	0
OLR1-010 ENSP00000340572 ENST00000339968	J3QTI8 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 12.1 kDa	No	0
OLR1-013 ENSP00000438744 ENST00000538873	F5H0N6 [Direct mapping] Oxidized low-density lipoprotein receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.7 kDa	No	0