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ARV1

GENERAL INFORMATION

Gene name

 ARV1

Gene description

 ARV1 homolog, fatty acid homeostasis modulator

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035709
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and colorectal cancer (favourable).
Lung cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035709

GENE INFORMATION

Gene name

 ARV1

Synonyms

Description

 ARV1 homolog, fatty acid homeostasis modulator (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q42.2

Chromosome location (bp)

 230978981 - 231000595

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173409 (version 83.38)

Entrez gene

 64801

UniProt

 Q9H2C2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9H2C2

Antibodypedia

 ARV1 antibodies

PROTEIN BROWSER
ARV1-001
ARV1-003
ARV1-005
ARV1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARV1-001
ENSP00000312458
ENST00000310256
Q9H2C2 [Direct mapping]
Protein ARV1
A0A024R3V6 [Target identity:100%; Query identity:100%]
ARV1 homolog (Yeast), isoform CRA_b
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Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006665 [sphingolipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0008206 [bile acid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0032366 [intracellular sterol transport]
GO:0032541 [cortical endoplasmic reticulum]
GO:0044281 [small molecule metabolic process]
GO:0090181 [regulation of cholesterol metabolic process]
GO:0097036 [regulation of plasma membrane sterol distribution]
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 271 aa
31.1 kDa 		No 5
ARV1-003
ENSP00000355618
ENST00000366658
A0A0A0MRI7 [Direct mapping]
Protein ARV1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006665 [sphingolipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0032366 [intracellular sterol transport]
GO:0032541 [cortical endoplasmic reticulum]
GO:0097036 [regulation of plasma membrane sterol distribution]
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 231 aa
26.4 kDa 		No 5
ARV1-005
ENSP00000394547
ENST00000435927
H7C0E7 [Direct mapping]
Protein ARV1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006665 [sphingolipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0032366 [intracellular sterol transport]
GO:0032541 [cortical endoplasmic reticulum]
GO:0097036 [regulation of plasma membrane sterol distribution]
Show all
 291 aa
33.1 kDa 		No 5
ARV1-007
ENSP00000416039
ENST00000450711
H7C484 [Direct mapping]
Protein ARV1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
GO:0006665 [sphingolipid metabolic process]
GO:0016021 [integral component of membrane]
GO:0016125 [sterol metabolic process]
GO:0032366 [intracellular sterol transport]
GO:0032541 [cortical endoplasmic reticulum]
GO:0097036 [regulation of plasma membrane sterol distribution]
Show all
 268 aa
30.7 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.