Expression of AGR3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AGR3
Gene description	Anterior gradient 3, protein disulphide isomerase family member
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (breast cancer)
HPA (cell line):	Cell line enriched (T-47d)
HPA (normal tissue):	Tissue enhanced (fallopian tube, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic and membranous expression in glandular cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA053942
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA053942

GENE INFORMATION
Gene name	AGR3 (HGNC Symbol)
Synonyms	BCMP11, hAG-3, HAG3, PDIA18
Description	Anterior gradient 3, protein disulphide isomerase family member (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	16859405 - 16881987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173467 (version 83.38)
Entrez gene	155465
UniProt	Q8TD06 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD06
Antibodypedia	AGR3 antibodies

PROTEIN BROWSER

AGR3-001	AGR3-002	AGR3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGR3-001 ENSP00000308606 ENST00000310398	Q8TD06 [Direct mapping] Anterior gradient protein 3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002162 [dystroglycan binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005783 [endoplasmic reticulum] GO:0008150 [biological_process] Show all	166 aa 19.2 kDa	Yes	0
AGR3-002 ENSP00000392818 ENST00000414935	H7C040 [Direct mapping] Anterior gradient protein 3 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.9 kDa	No	0
AGR3-004 ENSP00000386016 ENST00000402239	B5MC62 [Direct mapping] Anterior gradient protein 3 homolog Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.7 kDa	Yes	0