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PEAK1

GENERAL INFORMATION

Gene name

 PEAK1

Gene description

 Pseudopodium-enriched atypical kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in all cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA026313 , HPA026517
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA026313
HPA026517

GENE INFORMATION

Gene name

 PEAK1 (HGNC Symbol)

Synonyms

 KIAA2002, sgk269

Description

 Pseudopodium-enriched atypical kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]

Chromosome

 15

Cytoband

 q24.3

Chromosome location (bp)

 77100656 - 77420144

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173517 (version 83.38)

Entrez gene

 79834

UniProt

 Q9H792 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H792

Antibodypedia

 PEAK1 antibodies

PROTEIN BROWSER
PEAK1-001
PEAK1-005
PEAK1-006
PEAK1-012
PEAK1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEAK1-001
ENSP00000452796
ENST00000560626
Q9H792 [Direct mapping]
Pseudopodium-enriched atypical kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0046777 [protein autophosphorylation]
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 1746 aa
193.1 kDa 		No 0
PEAK1-005
ENSP00000453924
ENST00000558305
H0YN99 [Direct mapping]
Pseudopodium-enriched atypical kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
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 1049 aa
115.2 kDa 		No 0
PEAK1-006
ENSP00000457880
ENST00000564328
H3BUZ5 [Direct mapping]
Pseudopodium-enriched atypical kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
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 656 aa
72 kDa 		No 0
PEAK1-012
ENSP00000457602
ENST00000565820
H3BUE6 [Direct mapping]
Pseudopodium-enriched atypical kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
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 60 aa
6.7 kDa 		No 0
PEAK1-201
ENSP00000309230
ENST00000312493
Q9H792 [Direct mapping]
Pseudopodium-enriched atypical kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0046777 [protein autophosphorylation]
Show all
 1746 aa
193.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.