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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SNX33
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SNX33

Gene description

Sorting nexin 33

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA040988
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PROGNOSTIC SUMMARY

Prognostic marker in ovarian cancer (unfavourable).
Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040988

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity was observed in malignant cells. Renal cell carcinomas showed additional membranous staining.

GENE INFORMATION

Gene name

SNX33 (HGNC Symbol)

Synonyms

MGC32065, SH3PX3, SH3PXD3C, SNX30

Description

Sorting nexin 33 (HGNC Symbol)

Entrez gene summary

Chromosome

15

Cytoband

q24.2

Chromosome location (bp)

75647906 - 75662301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173548 (version 83.38)

Entrez gene

257364

UniProt

Q8WV41 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WV41

Antibodypedia

SNX33 antibodies

PROTEIN BROWSER

SNX33-001
SNX33-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNX33-001
ENSP00000311427
ENST00000308527
Q8WV41 [Direct mapping]
Sorting nexin-33
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007032 [endosome organization]
GO:0007067 [mitotic nuclear division]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016050 [vesicle organization]
GO:0016197 [endosomal transport]
GO:0017038 [protein import]
GO:0019898 [extrinsic component of membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0036089 [cleavage furrow formation]
GO:0042802 [identical protein binding]
GO:0044351 [macropinocytosis]
GO:0045806 [negative regulation of endocytosis]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0097320 [membrane tubulation]
GO:2000009 [negative regulation of protein localization to cell surface]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
574 aa
65.3 kDa
No 0
SNX33-002
ENSP00000455436
ENST00000569152
H3BPR3 [Direct mapping]
Sorting nexin-33
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0035091 [phosphatidylinositol binding]
Show all
283 aa
33.5 kDa
No 0

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