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NUDT4

GENERAL INFORMATION

Gene name

 NUDT4

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 3 antibodies.
HPA017593 , HPA047027 , HPA057684
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA017593
HPA047027
HPA057684

GENE INFORMATION

Gene name

 NUDT4 (HGNC Symbol)

Synonyms

 DIPP2, DIPP2alpha, DIPP2beta, HDCMB47P, KIAA0487

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q22

Chromosome location (bp)

 93377883 - 93408146

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173598 (version 83.38)

Entrez gene

 11163

UniProt

 Q9NZJ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZJ9

Antibodypedia

 NUDT4 antibodies

PROTEIN BROWSER
NUDT4-001
NUDT4-002
NUDT4-003
NUDT4-004
NUDT4-006
NUDT4-007
NUDT4-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT4-001
ENSP00000338352
ENST00000337179
Q9NZJ9 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
A0A024RBG1 [Target identity:100%; Query identity:100%]
Nudix (Nucleoside diphosphate linked moiety X)-type motif 4, isoform CRA_b
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0009187 [cyclic nucleotide metabolic process]
GO:0016787 [hydrolase activity]
GO:0019722 [calcium-mediated signaling]
GO:0019935 [cyclic-nucleotide-mediated signaling]
GO:0030515 [snoRNA binding]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
Show all
 181 aa
20.4 kDa 		No 0
NUDT4-002
ENSP00000406612
ENST00000415493
Q9NZJ9 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
A0A024RBD0 [Target identity:100%; Query identity:100%]
Nudix (Nucleoside diphosphate linked moiety X)-type motif 4, isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0009187 [cyclic nucleotide metabolic process]
GO:0016787 [hydrolase activity]
GO:0019722 [calcium-mediated signaling]
GO:0019935 [cyclic-nucleotide-mediated signaling]
GO:0030515 [snoRNA binding]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
Show all
 180 aa
20.3 kDa 		No 0
NUDT4-003
ENSP00000448032
ENST00000547014
Q9NZJ9 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0009187 [cyclic nucleotide metabolic process]
GO:0016787 [hydrolase activity]
GO:0019722 [calcium-mediated signaling]
GO:0019935 [cyclic-nucleotide-mediated signaling]
GO:0030515 [snoRNA binding]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046831 [regulation of RNA export from nucleus]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
Show all
 129 aa
14.4 kDa 		No 0
NUDT4-004
ENSP00000449552
ENST00000549992
A0A0C4DGJ4 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 128 aa
14.3 kDa 		No 0
NUDT4-006
ENSP00000448504
ENST00000550056
F8VRL4 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 95 aa
11 kDa 		No 0
NUDT4-007
ENSP00000448620
ENST00000546925
F8VRR0 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 112 aa
12.7 kDa 		No 0
NUDT4-008
ENSP00000449724
ENST00000548662
A0A0C4DGJ4 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 128 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.