Expression of GPRC6A in cancer - Summary - The Human Protein Atlas

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GPRC6A

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GPRC6A
Gene description	G protein-coupled receptor, class C, group 6, member A
Protein class	G-protein coupled receptors Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (renal cancer)
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GPRC6A (HGNC Symbol)
Synonyms	bA86F4.3
Description	G protein-coupled receptor, class C, group 6, member A (HGNC Symbol)
Entrez gene summary	Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
Chromosome	6
Cytoband	q22.1
Chromosome location (bp)	116792085 - 116829037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173612 (version 83.38)
Entrez gene	222545
UniProt	Q5T6X5 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T6X5
Antibodypedia	GPRC6A antibodies

PROTEIN BROWSER

GPRC6A-001	GPRC6A-002	GPRC6A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRC6A-001 ENSP00000309493 ENST00000310357	Q5T6X5 [Direct mapping] G-protein coupled receptor family C group 6 member A Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0043200 [response to amino acid] Show all	926 aa 104.8 kDa	Yes	7
GPRC6A-002 ENSP00000357537 ENST00000368549	Q5T6X5 [Direct mapping] G-protein coupled receptor family C group 6 member A Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0043200 [response to amino acid] Show all	855 aa 96.5 kDa	Yes	7
GPRC6A-003 ENSP00000433465 ENST00000530250	Q5T6X5 [Direct mapping] G-protein coupled receptor family C group 6 member A Show all	Family 3 (C) receptors Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0043200 [response to amino acid] Show all	751 aa 84.6 kDa	Yes	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.