Expression of APOBEC4 in cancer - Summary

GENERAL INFORMATION
Gene name	APOBEC4
Gene description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues. Distinct expression in internal elastic lamina of some vessels.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA015636 , HPA015637
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA015636	HPA015637

GENE INFORMATION
Gene name	APOBEC4 (HGNC Symbol)
Synonyms	C1orf169, FLJ25691, MGC26594, RP1-127C7.4
Description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	183646404 - 183653316
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173627 (version 83.38)
Entrez gene	403314
UniProt	Q8WW27 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WW27
Antibodypedia	APOBEC4 antibodies

PROTEIN BROWSER

APOBEC4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOBEC4-001 ENSP00000310622 ENST00000308641	Q8WW27 [Direct mapping] Putative C->U-editing enzyme APOBEC-4 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0006397 [mRNA processing] GO:0008270 [zinc ion binding] GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines] Show all	367 aa 41.6 kDa	No	0