Expression of RCE1 in cancer - Summary - The Human Protein Atlas

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RCE1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RCE1
Gene description	Ras converting CAAX endopeptidase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RCE1 (HGNC Symbol)
Synonyms	FACE-2, FACE2, hRCE1, RCE1A, RCE1B
Description	Ras converting CAAX endopeptidase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66842835 - 66846546
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173653 (version 83.38)
Entrez gene	9986
UniProt	Q9Y256 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y256
Antibodypedia	RCE1 antibodies

PROTEIN BROWSER

RCE1-001	RCE1-003	RCE1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCE1-001 ENSP00000309163 ENST00000309657	Q9Y256 [Direct mapping] CAAX prenyl protease 2 Show all	Enzymes Peptidases Threonine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0071586 [CAAX-box protein processing] Show all	329 aa 35.8 kDa	No	6
RCE1-003 ENSP00000436600 ENST00000524506	E9PI08 [Direct mapping] CAAX prenyl protease 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	308 aa 33.4 kDa	No	6
RCE1-004 ENSP00000435409 ENST00000525356	E9PKA7 [Direct mapping] CAAX prenyl protease 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	206 aa 22.7 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.