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EIF1AX

GENERAL INFORMATION

Gene name

 EIF1AX

Gene description

 Eukaryotic translation initiation factor 1A, X-linked

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA002561
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002561

GENE INFORMATION

Gene name

 EIF1AX (HGNC Symbol)

Synonyms

 eIF-1A, eIF-4C, EIF1A, EIF4C

Description

 Eukaryotic translation initiation factor 1A, X-linked (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 20124518 - 20141844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173674 (version 83.38)

Entrez gene

 1964

UniProt

 P47813 (UniProt - Evidence at protein level)

neXtProt

 NX_P47813

Antibodypedia

 EIF1AX antibodies

PROTEIN BROWSER
EIF1AX-001
EIF1AX-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF1AX-001
ENSP00000368927
ENST00000379607
P47813 [Direct mapping]
Eukaryotic translation initiation factor 1A, X-chromosomal
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 144 aa
16.5 kDa 		No 0
EIF1AX-002
ENSP00000368912
ENST00000379593
X6RAC9 [Direct mapping]
Eukaryotic translation initiation factor 1A, X-chromosomal
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0006413 [translational initiation]
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 116 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.