Expression of RNF213 in cancer - Summary - The Human Protein Atlas

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RNF213

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF213
Gene description	Ring finger protein 213
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA003347 , HPA026790
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA003347	HPA026790

GENE INFORMATION
Gene name	RNF213 (HGNC Symbol)
Synonyms	C17orf27, KIAA1554, KIAA1618, MYMY2, NET57
Description	Ring finger protein 213 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	80260866 - 80398786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173821 (version 83.38)
Entrez gene	57674
UniProt	Q63HN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q63HN8
Antibodypedia	RNF213 antibodies

PROTEIN BROWSER

RNF213-001	RNF213-002	RNF213-015	RNF213-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF213-001 ENSP00000425956 ENST00000508628	A0A0A0MTC1 [Direct mapping] E3 ubiquitin-protein ligase RNF213 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016887 [ATPase activity] GO:0046872 [metal ion binding] Show all	5256 aa 596.5 kDa	No	3
RNF213-002 ENSP00000324392 ENST00000319921	Q63HN8 [Direct mapping] E3 ubiquitin-protein ligase RNF213 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0016887 [ATPase activity] GO:0051865 [protein autoubiquitination] Show all	1063 aa 118.4 kDa	No	0
RNF213-015 ENSP00000460462 ENST00000573038	I3L3H9 [Direct mapping] E3 ubiquitin-protein ligase RNF213 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.7 kDa	No	0
RNF213-020 ENSP00000464087 ENST00000582970	A0A0A0MTR7 [Direct mapping] E3 ubiquitin-protein ligase RNF213 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016887 [ATPase activity] GO:0046872 [metal ion binding] Show all	5207 aa 591.4 kDa	No	3

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The Human Protein Atlas

The Human Protein Atlas project is funded
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