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KCNH6

GENERAL INFORMATION

Gene name

 KCNH6

Gene description

 Potassium channel, voltage gated eag related subfamily H, member 6

Protein class

 Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (kidney, prostate, small intestine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KCNH6 (HGNC Symbol)

Synonyms

 erg2, HERG2, Kv11.2

Description

 Potassium channel, voltage gated eag related subfamily H, member 6 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 63523334 - 63548977

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173826 (version 83.38)

Entrez gene

 81033

UniProt

 Q9H252 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H252

Antibodypedia

 KCNH6 antibodies

PROTEIN BROWSER
KCNH6-001
KCNH6-002
KCNH6-003
KCNH6-005
KCNH6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNH6-001
ENSP00000318212
ENST00000314672
J9JID4 [Direct mapping]
Potassium voltage-gated channel subfamily H member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 958 aa
106.4 kDa 		No 6
KCNH6-002
ENSP00000463830
ENST00000581784
Q9H252 [Direct mapping]
Potassium voltage-gated channel subfamily H member 6
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 905 aa
100.4 kDa 		No 5
KCNH6-003
ENSP00000464672
ENST00000580652
Q9H252 [Direct mapping]
Potassium voltage-gated channel subfamily H member 6
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 502 aa
56.3 kDa 		No 4
KCNH6-005
ENSP00000463533
ENST00000583023
Q9H252 [Direct mapping]
Potassium voltage-gated channel subfamily H member 6
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 994 aa
109.9 kDa 		No 5
KCNH6-201
ENSP00000396900
ENST00000456941
Q9H252 [Direct mapping]
Potassium voltage-gated channel subfamily H member 6
Show all
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0086091 [regulation of heart rate by cardiac conduction]
Show all
 905 aa
100.4 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.