Cell atlas - MARCH10 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MARCH10

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MARCH10
Gene description	Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA023322
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023322	A-431	Plasma membrane
	HPA023322	A-431	Cytosol
	HPA023322	U-2 OS	Plasma membrane
	HPA023322	U-2 OS	Cytosol
	HPA023322	U-251 MG	Plasma membrane
	HPA023322	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MARCH10 (HGNC Symbol)
Synonyms	FLJ35757, MARCH-X, RNF190
Description	Membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Chromosome	17
Cytoband	q23.2
Chromosome location (bp)	62701314 - 62808344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173838 (version 83.38)
Entrez gene	162333
UniProt	Q8NA82 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NA82
Antibodypedia	MARCH10 antibodies

PROTEIN BROWSER

MARCH10-001	MARCH10-002	MARCH10-003	MARCH10-004	MARCH10-005	MARCH10-006	MARCH10-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH10-001 ENSP00000311496 ENST00000311269	Q8NA82 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	808 aa 90.5 kDa	No	0
MARCH10-002 ENSP00000463080 ENST00000583600	J3KTN9 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10; Ring finger protein 190, isoform CRA_b Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	846 aa 94.6 kDa	No	0
MARCH10-003 ENSP00000443746 ENST00000544856	G3V1Q5 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10; Ring finger protein 190, isoform CRA_c Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	799 aa 89.8 kDa	No	0
MARCH10-004 ENSP00000416177 ENST00000456609	Q8NA82 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	808 aa 90.5 kDa	No	0
MARCH10-005 ENSP00000464220 ENST00000580520	J3QRH7 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	693 aa 76.9 kDa	No	0
MARCH10-006 ENSP00000463029 ENST00000583803	J3KTK3 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all		61 aa 7.7 kDa	No	0
MARCH10-008 ENSP00000463572 ENST00000582568	J3QLJ2 [Direct mapping] Probable E3 ubiquitin-protein ligase MARCH10 Show all	Predicted intracellular proteins Show all		164 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.