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NET1

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GENERAL INFORMATION

Gene name

 NET1

Gene description

 Neuroepithelial cell transforming 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

Additional location

 In addition localized to the Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA020068
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to vesicles.

Main location

 Nucleus (approved)

Additional location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA020068 A-431 Nucleus Spatial
Vesicles
HPA020068 HaCaT Nucleus Spatial
Vesicles Spatial
HPA020068 U-2 OS Nucleus
Vesicles

GENE INFORMATION

Gene name

 NET1 (HGNC Symbol)

Synonyms

 ARHGEF8, NET1A

Description

 Neuroepithelial cell transforming 1 (HGNC Symbol)

Entrez gene summary

 This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5412551 - 5458463

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173848 (version 83.38)

Entrez gene

 10276

UniProt

 Q7Z628 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z628

Antibodypedia

 NET1 antibodies

PROTEIN BROWSER
NET1-003
NET1-005
NET1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NET1-003
ENSP00000403101
ENST00000449083
Q5SQI6 [Direct mapping]
Neuroepithelial cell-transforming gene 1 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 160 aa
18.5 kDa 		No 0
NET1-005
ENSP00000347134
ENST00000355029
Q7Z628 [Direct mapping]
Neuroepithelial cell-transforming gene 1 protein
Q5SQI5 [Target identity:100%; Query identity:100%]
Neuroepithelial cell transforming gene 1, isoform CRA_b; cDNA FLJ50843, highly similar to Neuroepithelial cell-transforming gene 1 protein
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051451 [myoblast migration]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071479 [cellular response to ionizing radiation]
GO:0097190 [apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
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 596 aa
67.7 kDa 		No 0
NET1-006
ENSP00000369717
ENST00000380359
Q7Z628 [Direct mapping]
Neuroepithelial cell-transforming gene 1 protein
Q5SQI7 [Target identity:100%; Query identity:100%]
Neuroepithelial cell transforming gene 1, isoform CRA_a; cDNA, FLJ96638, Homo sapiens neuroepithelial cell transforming gene 1 (NET1), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071479 [cellular response to ionizing radiation]
GO:0097190 [apoptotic signaling pathway]
Show all
 542 aa
61.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.