Expression of GPR160 in cancer - Summary - The Human Protein Atlas

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GPR160

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR160
Gene description	G protein-coupled receptor 160
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (THP-1, U-266/70)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA006970
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006970

GENE INFORMATION
Gene name	GPR160 (HGNC Symbol)
Synonyms	GPCR1, GPCR150
Description	G protein-coupled receptor 160 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q26.2
Chromosome location (bp)	170037929 - 170085403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173890 (version 83.38)
Entrez gene	26996
UniProt	Q9UJ42 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UJ42
Antibodypedia	GPR160 antibodies

PROTEIN BROWSER

GPR160-001	GPR160-002	GPR160-007	GPR160-009	GPR160-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR160-001 ENSP00000348161 ENST00000355897	Q9UJ42 [Direct mapping] Probable G-protein coupled receptor 160 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	338 aa 39.8 kDa	No	7
GPR160-002 ENSP00000418531 ENST00000492492	C9J0J1 [Direct mapping] Probable G-protein-coupled receptor 160 Show all	Predicted intracellular proteins Show all		33 aa 3.9 kDa	No	0
GPR160-007 ENSP00000419546 ENST00000485735	C9JTZ7 [Direct mapping] Probable G-protein-coupled receptor 160 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	163 aa 19.2 kDa	No	4
GPR160-009 ENSP00000419400 ENST00000482710	C9JUZ9 [Direct mapping] Probable G-protein-coupled receptor 160 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	88 aa 10.3 kDa	No	2
GPR160-011 ENSP00000420751 ENST00000473675	C9JBW1 [Direct mapping] Probable G-protein-coupled receptor 160 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	143 aa 17 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.