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Most of the cancer tissues showed moderate to strong cytoplasmic and/or membranous positivity. Lymphomas and melanomas along with several testis, renal, urothelial and breast cancers were weakly stained or negative.
Most cancer tissues displayed moderate to strong cytoplasmic positivity, with a granular pattern. Several squamous cell carcinomas, gliomas and lymphomas were weakly stained or negative.
A majority of malignancies displayed weak to moderate membranous and cytoplasmic positivity. Prostate cancers and a few ovarian cancers were strongly stained. Malignant lymphomas, testicular and renal cancers were negative.
GENE INFORMATION
Gene name
SPTBN2 (HGNC Symbol)
Synonyms
SCA5
Description
Spectrin, beta, non-erythrocytic 2 (HGNC Symbol)
Entrez gene summary
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]