Expression of RBM4B in cancer - Summary

GENERAL INFORMATION
Gene name	RBM4B
Gene description	RNA binding motif protein 4B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression, including nuclear membranous expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA042174 , HPA047849
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042174	HPA047849

GENE INFORMATION
Gene name	RBM4B (HGNC Symbol)
Synonyms	MGC10871, RBM30, RBM4L, ZCCHC15, ZCCHC21B, ZCRB3B
Description	RNA binding motif protein 4B (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66664998 - 66677921
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173914 (version 83.38)
Entrez gene	83759
UniProt	Q9BQ04 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ04
Antibodypedia	RBM4B antibodies

PROTEIN BROWSER

RBM4B-001	RBM4B-002	RBM4B-003	RBM4B-004	RBM4B-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM4B-001 ENSP00000310471 ENST00000310046	Q9BQ04 [Direct mapping] RNA-binding protein 4B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0006417 [regulation of translation] GO:0007623 [circadian rhythm] GO:0008270 [zinc ion binding] GO:0008380 [RNA splicing] GO:0032922 [circadian regulation of gene expression] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0044822 [poly(A) RNA binding] Show all	359 aa 40.1 kDa	No	0
RBM4B-002 ENSP00000433071 ENST00000525754	Q9BQ04 [Direct mapping] RNA-binding protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0006417 [regulation of translation] GO:0007623 [circadian rhythm] GO:0008270 [zinc ion binding] GO:0008380 [RNA splicing] GO:0010628 [positive regulation of gene expression] GO:0032922 [circadian regulation of gene expression] GO:0043153 [entrainment of circadian clock by photoperiod] GO:0044822 [poly(A) RNA binding] Show all	359 aa 40.1 kDa	No	0
RBM4B-003 ENSP00000475784 ENST00000531036	U3KQD5 [Direct mapping] RNA-binding protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	151 aa 17.1 kDa	No	0
RBM4B-004 ENSP00000435239 ENST00000531969	E9PLB0 [Direct mapping] RNA-binding protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	143 aa 16.3 kDa	No	0
RBM4B-008 ENSP00000433113 ENST00000524637	E9PM61 [Direct mapping] RNA-binding protein 4B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	147 aa 16.8 kDa	No	0