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RBM4

GENERAL INFORMATION

Gene name

 RBM4

Gene description

 RNA binding motif protein 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression, including nuclear membranous expression in some tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA042174 , HPA047849
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042174
HPA047849

GENE INFORMATION

Gene name

 RBM4 (HGNC Symbol)

Synonyms

 LARK, RBM4A, ZCCHC21, ZCRB3A

Description

 RNA binding motif protein 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 66638617 - 66666682

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173933 (version 83.38)

Entrez gene

 5936

UniProt

 Q9BWF3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWF3

Antibodypedia

 RBM4 antibodies

PROTEIN BROWSER
«
RBM4-001
RBM4-002
RBM4-003
RBM4-007
RBM4-008
RBM4-009
RBM4-010
RBM4-011
RBM4-013
RBM4-014
RBM4-019
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM4-001
ENSP00000309166
ENST00000310092
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 364 aa
40.3 kDa 		No 0
RBM4-002
ENSP00000386561
ENST00000408993
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 364 aa
40.3 kDa 		No 0
RBM4-003
ENSP00000386894
ENST00000409406
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 364 aa
40.3 kDa 		No 0
RBM4-007
ENSP00000435821
ENST00000483858
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 177 aa
20 kDa 		No 0
RBM4-008
ENSP00000413497
ENST00000396053
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 173 aa
19.8 kDa 		No 0
RBM4-009
ENSP00000423572
ENST00000506523
D6R9K7 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 150 aa
17 kDa 		No 0
RBM4-010
ENSP00000381680
ENST00000398692
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 143 aa
16.2 kDa 		No 0
RBM4-011
ENSP00000432020
ENST00000532968
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 177 aa
20 kDa 		No 0
RBM4-013
ENSP00000432150
ENST00000530235
Q9BWF3 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0002190 [cap-independent translational initiation]
GO:0002192 [IRES-dependent translational initiation]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0017148 [negative regulation of translation]
GO:0030154 [cell differentiation]
GO:0032055 [negative regulation of translation in response to stress]
GO:0035198 [miRNA binding]
GO:0035278 [negative regulation of translation involved in gene silencing by miRNA]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0044822 [poly(A) RNA binding]
GO:0045947 [negative regulation of translational initiation]
GO:0046685 [response to arsenic-containing substance]
GO:0046822 [regulation of nucleocytoplasmic transport]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0097157 [pre-mRNA intronic binding]
GO:0097158 [pre-mRNA intronic pyrimidine-rich binding]
GO:0097167 [circadian regulation of translation]
Show all
 143 aa
16.2 kDa 		No 0
RBM4-014
ENSP00000422301
ENST00000510173
E9PB51 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 240 aa
26.3 kDa 		No 0
RBM4-019
ENSP00000464349
ENST00000578778
J3QRR5 [Direct mapping]
RNA-binding protein 4
Show all
Predicted intracellular proteins
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 155 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.