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UBXN2A

GENERAL INFORMATION

Gene name

 UBXN2A

Gene description

 UBX domain protein 2A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA065482 , HPA069096
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA065482
HPA069096

GENE INFORMATION

Gene name

 UBXN2A (HGNC Symbol)

Synonyms

 UBXD4

Description

 UBX domain protein 2A (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 23927285 - 24004909

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173960 (version 83.38)

Entrez gene

 165324

UniProt

 P68543 (UniProt - Evidence at transcript level)

neXtProt

 NX_P68543

Antibodypedia

 UBXN2A antibodies

PROTEIN BROWSER
UBXN2A-001
UBXN2A-003
UBXN2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBXN2A-001
ENSP00000312107
ENST00000309033
P68543 [Direct mapping]
UBX domain-containing protein 2A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000045 [autophagosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005801 [cis-Golgi network]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0010468 [regulation of gene expression]
GO:0031396 [regulation of protein ubiquitination]
GO:0031468 [nuclear envelope reassembly]
GO:0033130 [acetylcholine receptor binding]
GO:0042176 [regulation of protein catabolic process]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0061025 [membrane fusion]
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 259 aa
29.3 kDa 		No 0
UBXN2A-003
ENSP00000385525
ENST00000404924
P68543 [Direct mapping]
UBX domain-containing protein 2A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000045 [autophagosome assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031468 [nuclear envelope reassembly]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0061025 [membrane fusion]
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 259 aa
29.3 kDa 		No 0
UBXN2A-201
ENSP00000440533
ENST00000535786
P68543 [Direct mapping]
UBX domain-containing protein 2A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007030 [Golgi organization]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0031468 [nuclear envelope reassembly]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0061025 [membrane fusion]
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 206 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.