Expression of CEP19 in cancer - Summary - The Human Protein Atlas

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CEP19

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEP19
Gene description	Centrosomal protein 19kDa
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression most abundant in astrocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047614
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047614

GENE INFORMATION
Gene name	CEP19 (HGNC Symbol)
Synonyms	C3orf34, MGC14126
Description	Centrosomal protein 19kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to centrosomes and primary cilia and co-localizes with a marker for the mother centriole. This gene resides in a region of human chromosome 3 that is linked to morbid obesity. A homozygous knockout of the orthologous gene in mouse resulted in mice with morbid obesity, hyperphagy, glucose intolerance, and insulin resistance. Mutations in this gene cause morbid obesity and spermatogenic failure (MOSPGF). This gene has a pseudogene on human chromosome 2. [provided by RefSeq, Apr 2014]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	196706277 - 196712293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174007 (version 83.38)
Entrez gene	84984
UniProt	Q96LK0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LK0
Antibodypedia	CEP19 antibodies

PROTEIN BROWSER

CEP19-001	CEP19-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP19-001 ENSP00000387209 ENST00000409690	Q96LK0 [Direct mapping] Centrosomal protein of 19 kDa Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005814 [centriole] GO:0036064 [ciliary basal body] Show all	167 aa 19.6 kDa	No	0
CEP19-002 ENSP00000382823 ENST00000399942	A8MX07 [Direct mapping] Centrosomal protein of 19 kDa Show all	Predicted intracellular proteins Show all		128 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.