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FBXO45

GENERAL INFORMATION

Gene name

 FBXO45

Gene description

 F-box protein 45

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040730
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable), renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Prostate cancer p<0.001
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040730

GENE INFORMATION

Gene name

 FBXO45 (HGNC Symbol)

Synonyms

 Fbx45

Description

 F-box protein 45 (HGNC Symbol)

Entrez gene summary

 Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 196568611 - 196589059

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174013 (version 83.38)

Entrez gene

 200933

UniProt

 P0C2W1 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C2W1

Antibodypedia

 FBXO45 antibodies

PROTEIN BROWSER
FBXO45-001
FBXO45-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXO45-001
ENSP00000310332
ENST00000311630
P0C2W1 [Direct mapping]
F-box/SPRY domain-containing protein 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0014069 [postsynaptic density]
GO:0016567 [protein ubiquitination]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021957 [corticospinal tract morphogenesis]
GO:0021960 [anterior commissure morphogenesis]
GO:0030054 [cell junction]
GO:0042734 [presynaptic membrane]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0060384 [innervation]
GO:0060386 [synapse assembly involved in innervation]
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 286 aa
30.6 kDa 		No 0
FBXO45-002
ENSP00000389868
ENST00000440469
C9JLC0 [Direct mapping]
F-box/SPRY domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 107 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.