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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FBXO45
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FBXO45

Gene description

F-box protein 45

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA040730
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PROGNOSTIC SUMMARY

Prognostic marker in prostate cancer (unfavourable), renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Prostate cancer p<0.001
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040730

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer cells showed weak to moderate nuclear staining with additional cytoplasmic positivity in some cases. Many hepatocellular carcinomas, basal cell carcinomas, carcinoids, gliomas and renal cancers were negative.

GENE INFORMATION

Gene name

FBXO45 (HGNC Symbol)

Synonyms

Fbx45

Description

F-box protein 45 (HGNC Symbol)

Entrez gene summary

Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

Chromosome

3

Cytoband

q29

Chromosome location (bp)

196568611 - 196589059

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174013 (version 83.38)

Entrez gene

200933

UniProt

P0C2W1 (UniProt - Evidence at protein level)

neXtProt

NX_P0C2W1

Antibodypedia

FBXO45 antibodies

PROTEIN BROWSER

FBXO45-001
FBXO45-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXO45-001
ENSP00000310332
ENST00000311630
P0C2W1 [Direct mapping]
F-box/SPRY domain-containing protein 1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0014069 [postsynaptic density]
GO:0016567 [protein ubiquitination]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021957 [corticospinal tract morphogenesis]
GO:0021960 [anterior commissure morphogenesis]
GO:0030054 [cell junction]
GO:0042734 [presynaptic membrane]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0060384 [innervation]
GO:0060386 [synapse assembly involved in innervation]
Show all
286 aa
30.6 kDa
No 0
FBXO45-002
ENSP00000389868
ENST00000440469
C9JLC0 [Direct mapping]
F-box/SPRY domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
107 aa
11.9 kDa
No 0

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