Most cancer cells showed weak to moderate nuclear staining with additional cytoplasmic positivity in some cases. Many hepatocellular carcinomas, basal cell carcinomas, carcinoids, gliomas and renal cancers were negative.
FBXO45 (HGNC Symbol)
F-box protein 45 (HGNC Symbol)
Entrez gene summary
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]