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GNG5

GENERAL INFORMATION

Gene name

 GNG5

Gene description

 Guanine nucleotide binding protein (G protein), gamma 5

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA043651 , CAB032623
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GNG5

Synonyms

Description

 Guanine nucleotide binding protein (G protein), gamma 5 (HGNC Symbol)

Entrez gene summary

 G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 84498325 - 84506565

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174021 (version 83.38)

Entrez gene

 2787

UniProt

 P63218 (UniProt - Evidence at protein level)

neXtProt

 NX_P63218

Antibodypedia

 GNG5 antibodies

PROTEIN BROWSER
GNG5-001
GNG5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG5-001
ENSP00000359675
ENST00000370641
P63218 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030165 [PDZ domain binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 68 aa
7.3 kDa 		No 0
GNG5-002
ENSP00000359679
ENST00000370645
P63218 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030165 [PDZ domain binding]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
Show all
 68 aa
7.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.