Expression of MSRB3 in cancer - Summary - The Human Protein Atlas

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MSRB3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MSRB3
Gene description	Methionine sulfoxide reductase B3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA014432
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014432

GENE INFORMATION
Gene name	MSRB3 (HGNC Symbol)
Synonyms	DFNB74, DKFZp686C1178, FLJ36866
Description	Methionine sulfoxide reductase B3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	q14.3
Chromosome location (bp)	65278643 - 65488244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174099 (version 83.38)
Entrez gene	253827
UniProt	Q8IXL7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXL7
Antibodypedia	MSRB3 antibodies

PROTEIN BROWSER

MSRB3-001	MSRB3-002	MSRB3-003	MSRB3-004	MSRB3-005	MSRB3-008	MSRB3-010	MSRB3-011	MSRB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSRB3-001 ENSP00000347324 ENST00000355192	Q8IXL7 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006979 [response to oxidative stress] GO:0008270 [zinc ion binding] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	192 aa 20.7 kDa	Yes	0
MSRB3-002 ENSP00000312274 ENST00000308259	Q8IXL7 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006979 [response to oxidative stress] GO:0008270 [zinc ion binding] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	185 aa 20 kDa	No	0
MSRB3-003 ENSP00000441650 ENST00000535664	Q8IXL7 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006979 [response to oxidative stress] GO:0008270 [zinc ion binding] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	185 aa 20 kDa	No	0
MSRB3-004 ENSP00000445843 ENST00000535239	F5H199 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006979 [response to oxidative stress] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	164 aa 18.1 kDa	No	0
MSRB3-005 ENSP00000442620 ENST00000538045	F5H7C4 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006979 [response to oxidative stress] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	117 aa 13.1 kDa	No	0
MSRB3-008 ENSP00000437623 ENST00000540804	F5H6G9 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006979 [response to oxidative stress] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	160 aa 17.8 kDa	Yes	0
MSRB3-010 ENSP00000404903 ENST00000446731	H7C2B7 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006979 [response to oxidative stress] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	117 aa 13.2 kDa	No	0
MSRB3-011 ENSP00000440722 ENST00000541189	H0YFW5 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006979 [response to oxidative stress] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	174 aa 19.4 kDa	Yes	0
MSRB3-201 ENSP00000481483 ENST00000614640	Q8IXL7 [Direct mapping] Methionine-R-sulfoxide reductase B3 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0006979 [response to oxidative stress] GO:0008270 [zinc ion binding] GO:0030091 [protein repair] GO:0033743 [peptide-methionine (R)-S-oxide reductase activity] GO:0055114 [oxidation-reduction process] Show all	185 aa 20 kDa	No	0

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