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LEMD3

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GENERAL INFORMATION

Gene name

 LEMD3

Gene description

 LEM domain containing 3

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA076986
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear membrane.

Main location

 Nuclear membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA076986 RT4 Nuclear membrane
HPA076986 SiHa Nuclear membrane
HPA076986 U-2 OS Nuclear membrane

GENE INFORMATION

Gene name

 LEMD3 (HGNC Symbol)

Synonyms

 MAN1

Description

 LEM domain containing 3 (HGNC Symbol)

Entrez gene summary

 This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]

Chromosome

 12

Cytoband

 q14.3

Chromosome location (bp)

 65169571 - 65248327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174106 (version 83.38)

Entrez gene

 23592

UniProt

 Q9Y2U8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2U8

Antibodypedia

 LEMD3 antibodies

PROTEIN BROWSER
LEMD3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEMD3-001
ENSP00000308369
ENST00000308330
Q9Y2U8 [Direct mapping]
Inner nuclear membrane protein Man1
A0A024RBB9 [Target identity:100%; Query identity:100%]
LEM domain containing 3, isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0002044 [blood vessel endothelial cell migration involved in intussusceptive angiogenesis]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005639 [integral component of nuclear inner membrane]
GO:0006997 [nucleus organization]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0035914 [skeletal muscle cell differentiation]
GO:0051726 [regulation of cell cycle]
GO:1903053 [regulation of extracellular matrix organization]
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 911 aa
100 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.