Expression of FAM174A in cancer - Summary - The Human Protein Atlas

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FAM174A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM174A
Gene description	Family with sequence similarity 174, member A
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019539
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and renal cancer (favourable).
Glioma p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019539

GENE INFORMATION
Gene name	FAM174A (HGNC Symbol)
Synonyms	TMEM157, UNQ1912
Description	Family with sequence similarity 174, member A (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q21.1
Chromosome location (bp)	100535305 - 100586741
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174132 (version 83.38)
Entrez gene	345757
UniProt	Q8TBP5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TBP5
Antibodypedia	FAM174A antibodies

PROTEIN BROWSER

FAM174A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM174A-001 ENSP00000307954 ENST00000312637	Q8TBP5 [Direct mapping] Membrane protein FAM174A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	190 aa 20 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.