Expression of PIGG in cancer - Summary - The Human Protein Atlas

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PIGG

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIGG
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class G
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA015997
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015997

GENE INFORMATION
Gene name	PIGG (HGNC Symbol)
Synonyms	FLJ20265, GPI7, LAS21
Description	Phosphatidylinositol glycan anchor biosynthesis, class G (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	499210 - 540196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174227 (version 83.38)
Entrez gene	54872
UniProt	Q5H8A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5H8A4
Antibodypedia	PIGG antibodies

PROTEIN BROWSER

PIGG-001	PIGG-002	PIGG-003	PIGG-005	PIGG-006	PIGG-012	PIGG-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGG-001 ENSP00000415203 ENST00000453061	Q5H8A4 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051267 [CP2 mannose-ethanolamine phosphotransferase activity] Show all	983 aa 108.2 kDa	No	>9
PIGG-002 ENSP00000311750 ENST00000310340	Q5H8A4 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051267 [CP2 mannose-ethanolamine phosphotransferase activity] Show all	975 aa 107.4 kDa	No	>9
PIGG-003 ENSP00000372494 ENST00000383028	Q5H8A4 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051267 [CP2 mannose-ethanolamine phosphotransferase activity] Show all	850 aa 93.2 kDa	No	>9
PIGG-005 ENSP00000426002 ENST00000503111	Q5H8A4 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0016780 [phosphotransferase activity, for other substituted phosphate groups] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0051267 [CP2 mannose-ethanolamine phosphotransferase activity] Show all	299 aa 32.9 kDa	No	0
PIGG-006 ENSP00000421550 ENST00000509768	D6RFE8 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	480 aa 53 kDa	No	4
PIGG-012 ENSP00000424800 ENST00000504346	E7EWV1 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	894 aa 98.8 kDa	No	>9
PIGG-020 ENSP00000422410 ENST00000510235	D6RC16 [Direct mapping] GPI ethanolamine phosphate transferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030176 [integral component of endoplasmic reticulum membrane] Show all	24 aa 3 kDa	No	0

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