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TNK1

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GENERAL INFORMATION

Gene name

 TNK1

Gene description

 Tyrosine kinase, non-receptor, 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cell junctions.

RNA cell category

 Cell line enhanced (HaCaT, T-47d)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA056452
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cell junctions.

Main location

 Cell Junctions (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA056452 A-431 No staining    
HPA056452 MCF7 Cell Junctions
HPA056452 U-2 OS No staining    

GENE INFORMATION

Gene name

 TNK1

Synonyms

Description

 Tyrosine kinase, non-receptor, 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7380534 - 7389774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174292 (version 83.38)

Entrez gene

 8711

UniProt

 Q13470 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13470

Antibodypedia

 TNK1 antibodies

PROTEIN BROWSER
TNK1-001
TNK1-002
TNK1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNK1-001
ENSP00000459799
ENST00000576812
Q13470 [Direct mapping]
Non-receptor tyrosine-protein kinase TNK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0051427 [hormone receptor binding]
Show all
 666 aa
72.5 kDa 		No 0
TNK1-002
ENSP00000458834
ENST00000570896
Q13470 [Direct mapping]
Non-receptor tyrosine-protein kinase TNK1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0051427 [hormone receptor binding]
Show all
 661 aa
71.9 kDa 		No 0
TNK1-007
ENSP00000460146
ENST00000576716
I3L334 [Direct mapping]
Non-receptor tyrosine-protein kinase TNK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0051427 [hormone receptor binding]
Show all
 84 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.