Tissue expression of ZHX3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ZHX3
Gene description	Zinc fingers and homeoboxes 3
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ZHX3 (HGNC Symbol)
Synonyms	KIAA0395, TIX1
Description	Zinc fingers and homeoboxes 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q12
Chromosome location (bp)	41178448 - 41317672
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174306 (version 83.38)
Entrez gene	23051
UniProt	Q9H4I2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4I2
Antibodypedia	ZHX3 antibodies

PROTEIN BROWSER

ZHX3-001	ZHX3-002	ZHX3-004	ZHX3-005	ZHX3-006	ZHX3-007	ZHX3-008	ZHX3-009	ZHX3-010	ZHX3-011	ZHX3-013	ZHX3-019	ZHX3-021	ZHX3-022

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZHX3-001 ENSP00000454006 ENST00000560361	Q9H4I2 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	956 aa 104.7 kDa	No	0
ZHX3-002 ENSP00000443783 ENST00000544979	Q9H4I2 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	969 aa 106.3 kDa	No	0
ZHX3-004 ENSP00000453310 ENST00000559436	H0YLR4 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	127 aa 14.4 kDa	No	0
ZHX3-005 ENSP00000403048 ENST00000436440	A0A0A0MSU5 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	90 aa 9.6 kDa	No	0
ZHX3-006 ENSP00000453647 ENST00000560364	H0YNY7 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	315 aa 34 kDa	No	0
ZHX3-007 ENSP00000452965 ENST00000559234	Q9H4I2 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	956 aa 104.7 kDa	No	0
ZHX3-008 ENSP00000405421 ENST00000421422	H0Y6F5 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] Show all	678 aa 75.1 kDa	No	0
ZHX3-009 ENSP00000362358 ENST00000373261	F6UQN6 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	96 aa 10.3 kDa	No	0
ZHX3-010 ENSP00000312222 ENST00000309060	Q9H4I2 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	956 aa 104.7 kDa	No	0
ZHX3-011 ENSP00000415498 ENST00000432768	Q9H4I2 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0042803 [protein homodimerization activity] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] Show all	956 aa 104.7 kDa	No	0
ZHX3-013 ENSP00000454208 ENST00000558993	H0YNY7 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	315 aa 34 kDa	No	0
ZHX3-019 ENSP00000400441 ENST00000419740	F6UBH9 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	46 aa 4.9 kDa	No	0
ZHX3-021 ENSP00000399433 ENST00000441102	F6XGA7 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	118 aa 12.7 kDa	No	0
ZHX3-022 ENSP00000401852 ENST00000436099	A0A0A0MST6 [Direct mapping] Zinc fingers and homeoboxes protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] Show all	48 aa 5.1 kDa	No	0