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EXO1

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GENERAL INFORMATION

Gene name

 EXO1

Gene description

 Exonuclease 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA053079
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

 Nucleoplasm (supported)

Additional location

 Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053079 A-431 Nucleoplasm
Nuclear bodies
HPA053079 HEK 293 Nucleoplasm
HPA053079 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 EXO1 (HGNC Symbol)

Synonyms

 HEX1, hExoI

Description

 Exonuclease 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q43

Chromosome location (bp)

 241847967 - 241895148

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174371 (version 83.38)

Entrez gene

 9156

UniProt

 Q9UQ84 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ84

Antibodypedia

 EXO1 antibodies

PROTEIN BROWSER
EXO1-001
EXO1-002
EXO1-003
EXO1-004
EXO1-005
EXO1-008
EXO1-009
EXO1-011
EXO1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXO1-001
ENSP00000355506
ENST00000366548
Q9UQ84 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0002455 [humoral immune response mediated by circulating immunoglobulin]
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0008409 [5'-3' exonuclease activity]
GO:0016446 [somatic hypermutation of immunoglobulin genes]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0043566 [structure-specific DNA binding]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045145 [single-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0045190 [isotype switching]
GO:0046872 [metal ion binding]
GO:0048256 [flap endonuclease activity]
GO:0051321 [meiotic cell cycle]
GO:0051908 [double-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 846 aa
94.1 kDa 		No 0
EXO1-002
ENSP00000430251
ENST00000518483
Q9UQ84 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0008409 [5'-3' exonuclease activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045145 [single-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0046872 [metal ion binding]
GO:0048256 [flap endonuclease activity]
GO:0051321 [meiotic cell cycle]
GO:0051908 [double-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 803 aa
89.2 kDa 		No 0
EXO1-003
ENSP00000406652
ENST00000450748
Q5T399 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 135 aa
15.3 kDa 		No 0
EXO1-004
ENSP00000415531
ENST00000423131
Q5T397 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 169 aa
18.6 kDa 		No 0
EXO1-005
ENSP00000412041
ENST00000437497
Q5T398 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 166 aa
18.3 kDa 		No 0
EXO1-008
ENSP00000429720
ENST00000519225
E5RHK1 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 11 aa
1.2 kDa 		No 0
EXO1-009
ENSP00000430082
ENST00000523590
E5RGY3 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 95 aa
10.7 kDa 		No 0
EXO1-011
ENSP00000428326
ENST00000521202
H0YAZ2 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004518 [nuclease activity]
GO:0006281 [DNA repair]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 208 aa
22.6 kDa 		No 0
EXO1-201
ENSP00000311873
ENST00000348581
Q9UQ84 [Direct mapping]
Exonuclease 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003824 [catalytic activity]
GO:0004518 [nuclease activity]
GO:0004523 [RNA-DNA hybrid ribonuclease activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0008409 [5'-3' exonuclease activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0035312 [5'-3' exodeoxyribonuclease activity]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0045145 [single-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0046872 [metal ion binding]
GO:0048256 [flap endonuclease activity]
GO:0051321 [meiotic cell cycle]
GO:0051908 [double-stranded DNA 5'-3' exodeoxyribonuclease activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 846 aa
94.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.