Tissue expression of DENND4A - Summary - The Human Protein Atlas

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DENND4A

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DENND4A
Gene description	DENN/MADD domain containing 4A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic or nuclear expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA065343
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DENND4A (HGNC Symbol)
Synonyms	IRLB, MYCPBP
Description	DENN/MADD domain containing 4A (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65658046 - 65792293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174485 (version 83.38)
Entrez gene	10260
UniProt	Q7Z401 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z401
Antibodypedia	DENND4A antibodies

PROTEIN BROWSER

DENND4A-001	DENND4A-003	DENND4A-005	DENND4A-009	DENND4A-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND4A-001 ENSP00000391167 ENST00000443035	Q7Z401 [Direct mapping] C-myc promoter-binding protein Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] Show all	1906 aa 213.7 kDa	No	0
DENND4A-003 ENSP00000396830 ENST00000431932	Q7Z401 [Direct mapping] C-myc promoter-binding protein Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] Show all	1863 aa 209.2 kDa	No	0
DENND4A-005 ENSP00000457358 ENST00000564674	H3BTW5 [Direct mapping] C-myc promoter-binding protein Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1001 aa 112.6 kDa	No	0
DENND4A-009 ENSP00000456605 ENST00000561863	H3BSA0 [Direct mapping] C-myc promoter-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 2.8 kDa	No	0
DENND4A-010 ENSP00000489304 ENST00000635620		MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1916 aa 214.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.