Expression of PELI3 in cancer - Summary - The Human Protein Atlas

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PELI3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PELI3
Gene description	Pellino E3 ubiquitin protein ligase family member 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA038875 , HPA062281 , CAB033750
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038875	HPA062281	CAB033750

GENE INFORMATION
Gene name	PELI3 (HGNC Symbol)
Synonyms	MGC35521
Description	Pellino E3 ubiquitin protein ligase family member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66466327 - 66477337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174516 (version 83.38)
Entrez gene	246330
UniProt	Q8N2H9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N2H9
Antibodypedia	PELI3 antibodies

PROTEIN BROWSER

PELI3-001	PELI3-002	PELI3-004	PELI3-006	PELI3-007	PELI3-009	PELI3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PELI3-001 ENSP00000322532 ENST00000320740	Q8N2H9 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 A0A024R5B1 [Target identity:100%; Query identity:100%] Pellino homolog 3 (Drosophila), isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0008063 [Toll signaling pathway] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	469 aa 50.8 kDa	No	0
PELI3-002 ENSP00000309848 ENST00000349459	Q8N2H9 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 A0A024R5I2 [Target identity:100%; Query identity:100%] Pellino homolog 3 (Drosophila), isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0008063 [Toll signaling pathway] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	445 aa 48.2 kDa	No	0
PELI3-004 ENSP00000434677 ENST00000524466	Q8N2H9 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0008063 [Toll signaling pathway] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	331 aa 35.3 kDa	No	0
PELI3-006 ENSP00000432449 ENST00000527230	E9PQX6 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 Show all	Predicted intracellular proteins Show all	GO:0008063 [Toll signaling pathway] Show all	119 aa 12.6 kDa	No	0
PELI3-007 ENSP00000436722 ENST00000526296	E9PI91 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 Show all	Predicted intracellular proteins Show all	GO:0008063 [Toll signaling pathway] Show all	255 aa 27.7 kDa	No	0
PELI3-009 ENSP00000436161 ENST00000528752	H0YEM6 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 Show all	Predicted intracellular proteins Show all	GO:0008063 [Toll signaling pathway] Show all	67 aa 7.3 kDa	No	0
PELI3-201 ENSP00000484220 ENST00000618547	Q8N2H9 [Direct mapping] E3 ubiquitin-protein ligase pellino homolog 3 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0008063 [Toll signaling pathway] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	406 aa 44 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.