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MRPL11

GENERAL INFORMATION

Gene name

 MRPL11

Gene description

 Mitochondrial ribosomal protein L11

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA057685
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057685

GENE INFORMATION

Gene name

 MRPL11

Synonyms

Description

 Mitochondrial ribosomal protein L11 (HGNC Symbol)

Entrez gene summary

 This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 66435075 - 66466738

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174547 (version 83.38)

Entrez gene

 65003

UniProt

 Q9Y3B7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3B7

Antibodypedia

 MRPL11 antibodies

PROTEIN BROWSER
MRPL11-001
MRPL11-002
MRPL11-005
MRPL11-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL11-001
ENSP00000308897
ENST00000310999
Q9Y3B7 [Direct mapping]
39S ribosomal protein L11, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000027 [ribosomal large subunit assembly]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 192 aa
20.7 kDa 		No 0
MRPL11-002
ENSP00000415356
ENST00000430466
Q9Y3B7 [Direct mapping]
39S ribosomal protein L11, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 166 aa
18.2 kDa 		No 0
MRPL11-005
ENSP00000431405
ENST00000528272
H0YCD5 [Direct mapping]
39S ribosomal protein L11, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 63 aa
6.8 kDa 		No 0
MRPL11-006
ENSP00000329630
ENST00000329819
Q9Y3B7 [Direct mapping]
39S ribosomal protein L11, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
Show all
 181 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.