Expression of AKIRIN1 in cancer - Summary - The Human Protein Atlas

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AKIRIN1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AKIRIN1
Gene description	Akirin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051871
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051871

GENE INFORMATION
Gene name	AKIRIN1 (HGNC Symbol)
Synonyms	C1orf108, FLJ12666
Description	Akirin 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	38991223 - 39006059
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174574 (version 83.38)
Entrez gene	79647
UniProt	Q9H9L7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H9L7
Antibodypedia	AKIRIN1 antibodies

PROTEIN BROWSER

AKIRIN1-001	AKIRIN1-004	AKIRIN1-005	AKIRIN1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKIRIN1-001 ENSP00000392678 ENST00000432648	Q9H9L7 [Direct mapping] Akirin-1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0031965 [nuclear membrane] Show all	192 aa 21.9 kDa	No	0
AKIRIN1-004 ENSP00000389866 ENST00000446189	Q9H9L7 [Direct mapping] Akirin-1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0031965 [nuclear membrane] Show all	147 aa 16.5 kDa	No	0
AKIRIN1-005 ENSP00000362075 ENST00000372984	B4DQP0 [Direct mapping] Akirin-1; cDNA FLJ54126 Show all	Predicted intracellular proteins Show all		145 aa 16.5 kDa	No	0
AKIRIN1-007 ENSP00000436372 ENST00000531822	H0YEQ5 [Direct mapping] Akirin-1 Show all	Predicted intracellular proteins Show all		130 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.