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A few cases of melanomas showed weak to moderate cytoplasmic immunoreactivity. Other cancers were mainly negative.
GENE INFORMATION
Gene name
NPAS4 (HGNC Symbol)
Synonyms
bHLHe79, Le-PAS, NXF, PASD10
Description
Neuronal PAS domain protein 4 (HGNC Symbol)
Entrez gene summary
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]