Expression of IQCK in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	IQCK
Gene description	IQ motif containing K
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Expression also in cilia of fallopian tube, testis and endometrium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA026792
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA026792

GENE INFORMATION
Gene name	IQCK (HGNC Symbol)
Synonyms	FLJ36575, MGC35048
Description	IQ motif containing K (HGNC Symbol)
Entrez gene summary	This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19716456 - 19858467
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174628 (version 83.38)
Entrez gene	124152
UniProt	Q8N0W5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N0W5
Antibodypedia	IQCK antibodies

PROTEIN BROWSER

IQCK-001	IQCK-007	IQCK-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IQCK-001 ENSP00000324901 ENST00000320394	Q8N0W5 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		287 aa 33.3 kDa	No	0
IQCK-007 ENSP00000458669 ENST00000564186	I3L193 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		282 aa 32.8 kDa	No	0
IQCK-013 ENSP00000455504 ENST00000568061	H3BPX0 [Direct mapping] IQ domain-containing protein K Show all	Predicted intracellular proteins Show all		58 aa 6.2 kDa	No	0