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Gene name

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Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Specificity

Cell line

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Cancer

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Detectable

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Detectable

Cancer

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Antibodies

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LEP
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

LEP

Gene description

Leptin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (adipose tissue)
GTEx:Group enriched (adipose tissue, breast)
FANTOM5:Group enriched (adipose tissue, breast, placenta)

Protein evidence

Evidence at protein level

Protein expression

Positivity in plasma and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending retesting.

Reliability score

Approved based on 1 antibody.
CAB010490
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adipose tissue, breast, placenta)

GENE INFORMATION

Gene name

LEP (HGNC Symbol)

Synonyms

OB, OBS

Description

Leptin (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

128241284 - 128257628

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174697 (version 83.38)

Entrez gene

3952

UniProt

P41159 (UniProt - Evidence at protein level)

neXtProt

NX_P41159

Antibodypedia

LEP antibodies

PROTEIN BROWSER

LEP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEP-001
ENSP00000312652
ENST00000308868
P41159 [Direct mapping]
Leptin
A4D0Y8 [Target identity:100%; Query identity:100%]
Leptin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001542 [ovulation from ovarian follicle]
GO:0001666 [response to hypoxia]
GO:0001819 [positive regulation of cytokine production]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0002021 [response to dietary excess]
GO:0003300 [cardiac muscle hypertrophy]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0005737 [cytoplasm]
GO:0006006 [glucose metabolic process]
GO:0006111 [regulation of gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006114 [glycerol biosynthetic process]
GO:0006629 [lipid metabolic process]
GO:0006635 [fatty acid beta-oxidation]
GO:0007165 [signal transduction]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007565 [female pregnancy]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0008083 [growth factor activity]
GO:0008203 [cholesterol metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0008343 [adult feeding behavior]
GO:0009062 [fatty acid catabolic process]
GO:0009892 [negative regulation of metabolic process]
GO:0010888 [negative regulation of lipid storage]
GO:0014823 [response to activity]
GO:0019222 [regulation of metabolic process]
GO:0021954 [central nervous system neuron development]
GO:0030073 [insulin secretion]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031667 [response to nutrient levels]
GO:0032099 [negative regulation of appetite]
GO:0032355 [response to estradiol]
GO:0032868 [response to insulin]
GO:0033197 [response to vitamin E]
GO:0033210 [leptin-mediated signaling pathway]
GO:0033686 [positive regulation of luteinizing hormone secretion]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042445 [hormone metabolic process]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042593 [glucose homeostasis]
GO:0042755 [eating behavior]
GO:0043066 [negative regulation of apoptotic process]
GO:0043270 [positive regulation of ion transport]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045471 [response to ethanol]
GO:0045598 [regulation of fat cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0045906 [negative regulation of vasoconstriction]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046881 [positive regulation of follicle-stimulating hormone secretion]
GO:0048639 [positive regulation of developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050810 [regulation of steroid biosynthetic process]
GO:0050901 [leukocyte tethering or rolling]
GO:0051428 [peptide hormone receptor binding]
GO:0060587 [regulation of lipoprotein lipid oxidation]
GO:0060612 [adipose tissue development]
GO:0061037 [negative regulation of cartilage development]
GO:0070093 [negative regulation of glucagon secretion]
GO:0071298 [cellular response to L-ascorbic acid]
GO:0071300 [cellular response to retinoic acid]
GO:1900180 [regulation of protein localization to nucleus]
GO:1904651 [positive regulation of fat cell apoptotic process]
GO:2000366 [positive regulation of STAT protein import into nucleus]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000486 [negative regulation of glutamine transport]
GO:2000491 [positive regulation of hepatic stellate cell activation]
Show all
167 aa
18.6 kDa
Yes 0

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