Cell atlas - BRMS1 - The Human Protein Atlas

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BRMS1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	BRMS1
Gene description	Breast cancer metastasis suppressor 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019637
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome.

Main location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019637	A-431	Centrosome
	HPA019637	U-2 OS	No staining
	HPA019637	U-251 MG	Centrosome

GENE INFORMATION
Gene name	BRMS1 (HGNC Symbol)
Synonyms	DKFZP564A063
Description	Breast cancer metastasis suppressor 1 (HGNC Symbol)
Entrez gene summary	This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66337333 - 66345125
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174744 (version 83.38)
Entrez gene	25855
UniProt	Q9HCU9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCU9
Antibodypedia	BRMS1 antibodies

PROTEIN BROWSER

BRMS1-001	BRMS1-002	BRMS1-005	BRMS1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRMS1-001 ENSP00000353042 ENST00000359957	Q9HCU9 [Direct mapping] Breast cancer metastasis-suppressor 1 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0016575 [histone deacetylation] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0042826 [histone deacetylase binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051059 [NF-kappaB binding] GO:0070822 [Sin3-type complex] GO:0090312 [positive regulation of protein deacetylation] GO:2000210 [positive regulation of anoikis] Show all	246 aa 28.5 kDa	No	0
BRMS1-002 ENSP00000396052 ENST00000425825	G5E9I4 [Direct mapping] Breast cancer metastasis suppressor 1, isoform CRA_c; Breast cancer metastasis-suppressor 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0009987 [cellular process] GO:0016575 [histone deacetylation] GO:0042826 [histone deacetylase binding] GO:0070822 [Sin3-type complex] Show all	290 aa 33.7 kDa	No	0
BRMS1-005 ENSP00000433740 ENST00000530756	E9PJF5 [Direct mapping] Breast cancer metastasis-suppressor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0016575 [histone deacetylation] GO:0042826 [histone deacetylase binding] GO:0070822 [Sin3-type complex] Show all	244 aa 28.3 kDa	No	0
BRMS1-008 ENSP00000431510 ENST00000524699	H0YCF7 [Direct mapping] Breast cancer metastasis-suppressor 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0016575 [histone deacetylation] GO:0042826 [histone deacetylase binding] GO:0070822 [Sin3-type complex] Show all	267 aa 31.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.