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CEP135

GENERAL INFORMATION

Gene name

 CEP135

Gene description

 Centrosomal protein 135kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CEP135 (HGNC Symbol)

Synonyms

 CEP4, FLJ13621, KIAA0635

Description

 Centrosomal protein 135kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 55948871 - 56033363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174799 (version 83.38)

Entrez gene

 9662

UniProt

 Q66GS9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q66GS9

Antibodypedia

 CEP135 antibodies

PROTEIN BROWSER
CEP135-001
CEP135-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEP135-001
ENSP00000257287
ENST00000257287
Q66GS9 [Direct mapping]
Centrosomal protein of 135 kDa
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0008022 [protein C-terminus binding]
GO:0010457 [centriole-centriole cohesion]
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 1140 aa
133.5 kDa 		No 0
CEP135-002
ENSP00000412799
ENST00000422247
Q66GS9 [Direct mapping]
Centrosomal protein of 135 kDa
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0007099 [centriole replication]
GO:0008022 [protein C-terminus binding]
GO:0010457 [centriole-centriole cohesion]
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 249 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.