Tissue expression of ADGRE1 - Summary - The Human Protein Atlas

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ADGRE1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADGRE1
Gene description	Adhesion G protein-coupled receptor E1
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, spleen)
GTEx:	Tissue enriched (spleen)
FANTOM5:	Tissue enriched (spleen)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic expression in several tissues, including a subset of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA052809
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (spleen)

GENE INFORMATION
Gene name	ADGRE1 (HGNC Symbol)
Synonyms	EMR1, TM7LN3
Description	Adhesion G protein-coupled receptor E1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	19
Cytoband
Chromosome location (bp)	6887566 - 6940459
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174837 (version 83.38)
Entrez gene	2015
UniProt	Q14246 (UniProt - Evidence at transcript level)
neXtProt	NX_Q14246
Antibodypedia	ADGRE1 antibodies

PROTEIN BROWSER

ADGRE1-001	ADGRE1-002	ADGRE1-003	ADGRE1-004	ADGRE1-005	ADGRE1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRE1-001 ENSP00000250572 ENST00000250572	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	821 aa 90.4 kDa	Yes	5
ADGRE1-002 ENSP00000311545 ENST00000312053	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071944 [cell periphery] Show all	886 aa 97.7 kDa	Yes	7
ADGRE1-003 ENSP00000370814 ENST00000381407	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	745 aa 82.8 kDa	Yes	7
ADGRE1-004 ENSP00000370811 ENST00000381404	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	867 aa 95.9 kDa	Yes	7
ADGRE1-005 ENSP00000405974 ENST00000450315	Q14246 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	709 aa 78.9 kDa	Yes	7
ADGRE1-008 ENSP00000472553 ENST00000595026	M0R2G7 [Direct mapping] Adhesion G protein-coupled receptor E1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	319 aa 34.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.