Expression of PDE12 in cancer - Summary - The Human Protein Atlas

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PDE12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDE12
Gene description	Phosphodiesterase 12
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA043171
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043171

GENE INFORMATION
Gene name	PDE12 (HGNC Symbol)
Synonyms	2'-PDE, DKFZp667B1218
Description	Phosphodiesterase 12 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	57556276 - 57566844
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174840 (version 83.38)
Entrez gene	201626
UniProt	Q6L8Q7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6L8Q7
Antibodypedia	PDE12 antibodies

PROTEIN BROWSER

PDE12-001	PDE12-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE12-001 ENSP00000309142 ENST00000311180	Q6L8Q7 [Direct mapping] 2',5'-phosphodiesterase 12 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004535 [poly(A)-specific ribonuclease activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006397 [mRNA processing] GO:0046872 [metal ion binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	609 aa 67.4 kDa	No	0
PDE12-002 ENSP00000420626 ENST00000487257	F6T1Q0 [Direct mapping] 2',5'-phosphodiesterase 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		472 aa 52.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.