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This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001570 [vasculogenesis] GO:0001843 [neural tube closure] GO:0005171 [hepatocyte growth factor receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0031397 [negative regulation of protein ubiquitination] GO:0031461 [cullin-RING ubiquitin ligase complex] GO:0031462 [Cul2-RING ubiquitin ligase complex] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032434 [regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0040029 [regulation of gene expression, epigenetic] GO:0042130 [negative regulation of T cell proliferation] GO:0042327 [positive regulation of phosphorylation] GO:0042692 [muscle cell differentiation] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0050715 [positive regulation of cytokine secretion] GO:0055105 [ubiquitin-protein transferase inhibitor activity] GO:0072359 [circulatory system development]