Expression of AMY1B in cancer - Summary

GENERAL INFORMATION
Gene name	AMY1B
Gene description	Amylase, alpha 1B (salivary)
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in salivary gland and pancreatic exocrine glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA045394 , HPA045399 , HPA046980
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA045394	HPA045399	HPA046980

GENE INFORMATION
Gene name	AMY1B (HGNC Symbol)
Synonyms	AMY1
Description	Amylase, alpha 1B (salivary) (HGNC Symbol)
Entrez gene summary	Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	103687415 - 103696680
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174876 (version 83.38)
Entrez gene	277
UniProt	P04745 (UniProt - Evidence at protein level)
neXtProt	NX_P04745
Antibodypedia	AMY1B antibodies

PROTEIN BROWSER

AMY1B-001	AMY1B-002	AMY1B-003	AMY1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMY1B-001 ENSP00000359097 ENST00000370080	P04745 [Direct mapping] Alpha-amylase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.8 kDa	Yes	0
AMY1B-002 ENSP00000390219 ENST00000446703	Q5T085 [Direct mapping] Alpha-amylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005975 [carbohydrate metabolic process] GO:0043169 [cation binding] Show all	226 aa 25.6 kDa	Yes	0
AMY1B-003 ENSP00000393584 ENST00000425410	Q5T084 [Direct mapping] Alpha-amylase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	105 aa 12.4 kDa	Yes	0
AMY1B-201 ENSP00000330484 ENST00000330330	P04745 [Direct mapping] Alpha-amylase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.8 kDa	Yes	0