Expression of RSRC1 in cancer - Summary - The Human Protein Atlas

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RSRC1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RSRC1
Gene description	Arginine/serine-rich coiled-coil 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA044792
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044792

GENE INFORMATION
Gene name	RSRC1 (HGNC Symbol)
Synonyms	BM-011, MGC12197, SFRS21, SRrp53
Description	Arginine/serine-rich coiled-coil 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Chromosome	3
Cytoband	q25.32
Chromosome location (bp)	158105855 - 158545730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174891 (version 83.38)
Entrez gene	51319
UniProt	Q96IZ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IZ7
Antibodypedia	RSRC1 antibodies

PROTEIN BROWSER

RSRC1-001	RSRC1-002	RSRC1-003	RSRC1-004	RSRC1-006	RSRC1-007	RSRC1-008	RSRC1-010	RSRC1-012	RSRC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RSRC1-001 ENSP00000295930 ENST00000295930	Q96IZ7 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006913 [nucleocytoplasmic transport] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] Show all	334 aa 38.7 kDa	No	0
RSRC1-002 ENSP00000419794 ENST00000464171	Q96IZ7 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006913 [nucleocytoplasmic transport] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] Show all	276 aa 31.5 kDa	No	0
RSRC1-003 ENSP00000417302 ENST00000471994	C9J367 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 23.9 kDa	No	0
RSRC1-004 ENSP00000308671 ENST00000312179	Q96IZ7 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006913 [nucleocytoplasmic transport] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] Show all	276 aa 31.5 kDa	No	0
RSRC1-006 ENSP00000417816 ENST00000475278	C9J713 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		283 aa 33.4 kDa	No	0
RSRC1-007 ENSP00000420150 ENST00000480820	Q96IZ7 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006913 [nucleocytoplasmic transport] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] Show all	334 aa 38.7 kDa	No	0
RSRC1-008 ENSP00000417690 ENST00000494002	C9J8Q2 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 20 kDa	No	0
RSRC1-010 ENSP00000419394 ENST00000476899	C9JVB3 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		194 aa 23 kDa	No	0
RSRC1-012 ENSP00000420464 ENST00000482822	H7C5Q0 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 23.4 kDa	No	0
RSRC1-201 ENSP00000481697 ENST00000611884	Q96IZ7 [Direct mapping] Serine/Arginine-related protein 53 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006913 [nucleocytoplasmic transport] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0046677 [response to antibiotic] Show all	334 aa 38.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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