Expression of SEZ6L2 in cancer - Summary - The Human Protein Atlas

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SEZ6L2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SEZ6L2
Gene description	Seizure related 6 homolog (mouse)-like 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, mainly in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA064471
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable), glioma (unfavourable) and cervical cancer (unfavourable).
Colorectal cancer p<0.001 Glioma p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA064471

GENE INFORMATION
Gene name	SEZ6L2 (HGNC Symbol)
Synonyms	FLJ90517, PSK-1
Description	Seizure related 6 homolog (mouse)-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	29871159 - 29899547
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174938 (version 83.38)
Entrez gene	26470
UniProt	Q6UXD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXD5
Antibodypedia	SEZ6L2 antibodies

PROTEIN BROWSER

SEZ6L2-001	SEZ6L2-002	SEZ6L2-003	SEZ6L2-007	SEZ6L2-008	SEZ6L2-201	SEZ6L2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEZ6L2-001 ENSP00000310206 ENST00000350527	Q6UXD5 [Direct mapping] Seizure 6-like protein 2 A0A0A8K8P7 [Target identity:100%; Query identity:100%] Type I transmembrane receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	853 aa 92.5 kDa	Yes	1
SEZ6L2-002 ENSP00000312550 ENST00000308713	Q6UXD5 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	910 aa 97.6 kDa	Yes	1
SEZ6L2-003 ENSP00000319215 ENST00000346932	Q6UXD5 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	809 aa 86.9 kDa	Yes	1
SEZ6L2-007 ENSP00000454654 ENST00000563118	H3BN26 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		303 aa 32.9 kDa	No	0
SEZ6L2-008 ENSP00000458490 ENST00000568380	I3L111 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.3 kDa	Yes	0
SEZ6L2-201 ENSP00000439412 ENST00000537485	Q6UXD5 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	879 aa 94.5 kDa	Yes	1
SEZ6L2-202 ENSP00000481917 ENST00000617533	A0A087WYL5 [Direct mapping] Seizure 6-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0008344 [adult locomotory behavior] GO:0016021 [integral component of membrane] GO:0021680 [cerebellar Purkinje cell layer development] GO:0043025 [neuronal cell body] GO:0060074 [synapse maturation] GO:0090036 [regulation of protein kinase C signaling] Show all	923 aa 99.1 kDa	Yes	1

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