Expression of P2RY14 in cancer - Summary - The Human Protein Atlas

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P2RY14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	P2RY14
Gene description	Purinergic receptor P2Y, G-protein coupled, 14
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB022646
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB022646

GENE INFORMATION
Gene name	P2RY14 (HGNC Symbol)
Synonyms	GPR105, KIAA0001
Description	Purinergic receptor P2Y, G-protein coupled, 14 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	151212117 - 151278467
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000174944 (version 83.38)
Entrez gene	9934
UniProt	Q15391 (UniProt - Evidence at transcript level)
neXtProt	NX_Q15391
Antibodypedia	P2RY14 antibodies

PROTEIN BROWSER

P2RY14-001	P2RY14-002	P2RY14-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P2RY14-001 ENSP00000308361 ENST00000309170	Q15391 [Direct mapping] P2Y purinoceptor 14 A5JUU3 [Target identity:100%; Query identity:100%] Purinergic receptor P2Y G-protein coupled 14 transcript variant 2; Purinergic receptor P2Y, G-protein coupled, 14, isoform CRA_a; cDNA FLJ75398, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] GO:0045029 [UDP-activated nucleotide receptor activity] Show all	338 aa 39 kDa	No	7
P2RY14-002 ENSP00000408733 ENST00000424796	Q15391 [Direct mapping] P2Y purinoceptor 14 A5JUU3 [Target identity:100%; Query identity:100%] Purinergic receptor P2Y G-protein coupled 14 transcript variant 2; Purinergic receptor P2Y, G-protein coupled, 14, isoform CRA_a; cDNA FLJ75398, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 14, mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] GO:0045029 [UDP-activated nucleotide receptor activity] Show all	338 aa 39 kDa	No	7
P2RY14-003 ENSP00000418065 ENST00000494668	C9JAB5 [Direct mapping] P2Y purinoceptor 14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] Show all	96 aa 10.7 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.