Expression of AMZ1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AMZ1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMZ1
Gene description	Archaelysin family metallopeptidase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, MCF7, T-47d)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA020233
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020233

GENE INFORMATION
Gene name	AMZ1 (HGNC Symbol)
Synonyms	KIAA1950
Description	Archaelysin family metallopeptidase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	2679522 - 2775500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174945 (version 83.38)
Entrez gene	155185
UniProt	Q400G9 (UniProt - Evidence at protein level)
neXtProt	NX_Q400G9
Antibodypedia	AMZ1 antibodies

PROTEIN BROWSER

AMZ1-001	AMZ1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMZ1-001 ENSP00000308149 ENST00000312371	Q400G9 [Direct mapping] Archaemetzincin-1 A4D202 [Target identity:100%; Query identity:100%] Archaelysin family metallopeptidase 1; Archaemetzincin-1, isoform CRA_a; KIAA1950 protein; cDNA FLJ76739, highly similar to Homo sapiens archaemetzincin-1 (AMZ1), mRNA Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	498 aa 54.9 kDa	No	0
AMZ1-002 ENSP00000386020 ENST00000407112	Q400G9 [Direct mapping] Archaemetzincin-1 Show all	Enzymes Peptidases Metallopeptidases Predicted intracellular proteins Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0046872 [metal ion binding] Show all	297 aa 31.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.