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CTBP2

GENERAL INFORMATION

Gene name

 CTBP2

Gene description

 C-terminal binding protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression at variable levels in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 4 antibodies.
HPA023559 , HPA023564 , HPA044971 , CAB031916
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023559
HPA023564
HPA044971
CAB031916

GENE INFORMATION

Gene name

 CTBP2 (HGNC Symbol)

Synonyms

 ribeye

Description

 C-terminal binding protein 2 (HGNC Symbol)

Entrez gene summary

 This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 10

Cytoband

 q26.13

Chromosome location (bp)

 124984317 - 125161170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175029 (version 83.38)

Entrez gene

 1488

UniProt

 P56545 (UniProt - Evidence at protein level)

neXtProt

 NX_P56545

Antibodypedia

 CTBP2 antibodies

PROTEIN BROWSER
CTBP2-001
CTBP2-002
CTBP2-003
CTBP2-005
CTBP2-006
CTBP2-011
CTBP2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTBP2-001
ENSP00000338615
ENST00000337195
P56545 [Direct mapping]
C-terminal-binding protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
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 445 aa
48.9 kDa 		No 0
CTBP2-002
ENSP00000436285
ENST00000494626
P56545 [Direct mapping]
C-terminal-binding protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
Show all
 445 aa
48.9 kDa 		No 0
CTBP2-003
ENSP00000434630
ENST00000531469
P56545 [Direct mapping]
C-terminal-binding protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
Show all
 445 aa
48.9 kDa 		No 0
CTBP2-005
ENSP00000357816
ENST00000334808
Q5SQP8 [Direct mapping]
C-terminal-binding protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 513 aa
56.1 kDa 		No 0
CTBP2-006
ENSP00000311825
ENST00000309035
P56545 [Direct mapping]
C-terminal-binding protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0035563 [positive regulation of chromatin binding]
GO:0042803 [protein homodimerization activity]
GO:0042974 [retinoic acid receptor binding]
GO:0045202 [synapse]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
GO:0097470 [ribbon synapse]
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 985 aa
106.2 kDa 		No 0
CTBP2-011
ENSP00000410474
ENST00000411419
P56545 [Direct mapping]
C-terminal-binding protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0017053 [transcriptional repressor complex]
GO:0019079 [viral genome replication]
GO:0030054 [cell junction]
GO:0042803 [protein homodimerization activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048386 [positive regulation of retinoic acid receptor signaling pathway]
GO:0050872 [white fat cell differentiation]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070404 [NADH binding]
Show all
 445 aa
48.9 kDa 		No 0
CTBP2-014
ENSP00000434424
ENST00000530884
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.